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Target
Glucagon receptor
Ligand
BDBM50199490
Substrate
n/a
Meas. Tech.
ChEMBL_441039 (CHEMBL890126)
IC50
46±n/a nM
Citation
 Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett 17:587-92 (2007) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50199490
Synonyms:
3-(1-(3-(3,5-bis(trifluoromethyl)phenyl)-1-((1r,4r)-4-tert-butylcyclohexyl)ureido)-2,3-dihydro-1H-indene-5-carboxamido)propanoic acid | CHEMBL411833
Type:
Small organic molecule
Emp. Form.:
C32H37F6N3O4
Mol. Mass.:
641.6443
SMILES:
CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |w:11.11,wU:7.10,wD:4.3,(-2.57,-20.33,;-2.56,-18.79,;-1.02,-18.8,;-4.1,-18.79,;-2.55,-17.25,;-1.22,-16.48,;-1.21,-14.94,;-2.53,-14.18,;-3.88,-14.94,;-3.88,-16.48,;-2.54,-12.64,;-1.2,-11.87,;-.88,-10.37,;.98,-10.4,;1.45,-11.86,;2.79,-12.62,;2.79,-14.17,;1.46,-14.94,;.12,-14.17,;.13,-12.63,;4.13,-14.93,;4.13,-16.47,;5.46,-14.16,;6.8,-14.93,;8.13,-14.16,;9.46,-14.92,;10.79,-14.15,;9.47,-16.46,;-3.87,-11.87,;-3.87,-10.33,;-5.2,-12.64,;-6.54,-11.87,;-6.54,-10.32,;-7.88,-9.56,;-9.21,-10.33,;-9.21,-11.87,;-7.88,-12.64,;-10.55,-12.64,;-11.88,-13.4,;-9.78,-13.98,;-11.31,-11.3,;-7.89,-8.02,;-7.91,-6.47,;-6.35,-8.01,;-9.43,-8.03,)|
Structure:
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