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Target
Gastric inhibitory polypeptide receptor
Ligand
BDBM50199503
Substrate
n/a
Meas. Tech.
ChEMBL_441040 (CHEMBL890127)
IC50
610±n/a nM
Citation
 Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett 17:587-92 (2007) [PubMed]  Article 
Target
Name:
Gastric inhibitory polypeptide receptor
Synonyms:
GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor
Type:
PROTEIN
Mol. Mass.:
53173.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1518286
Residue:
466
Sequence:
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
  
Inhibitor
Name:
BDBM50199503
Synonyms:
1-(N-((1r,4r)-4-tert-butylcyclohexyl)-4-(trifluoromethoxy)benzamido)-N-(2H-tetrazol-5-yl)-2,3-dihydro-1H-indene-5-carboxamide | CHEMBL232037
Type:
Small organic molecule
Emp. Form.:
C29H33F3N6O3
Mol. Mass.:
570.6059
SMILES:
CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)c1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(22.77,-54.03,;22.78,-52.49,;24.32,-52.5,;21.24,-52.49,;22.78,-50.95,;24.11,-50.18,;24.11,-48.63,;22.77,-47.88,;21.44,-48.65,;21.44,-50.18,;22.77,-46.34,;24.1,-45.57,;24.25,-44.03,;25.75,-43.7,;26.53,-45.03,;28.02,-45.34,;28.51,-46.79,;27.48,-47.94,;25.98,-47.62,;25.5,-46.17,;30.01,-47.1,;30.5,-48.56,;31.04,-45.95,;32.55,-46.26,;33.19,-47.66,;34.72,-47.49,;35.03,-45.98,;33.69,-45.22,;21.43,-45.58,;21.42,-44.04,;20.1,-46.35,;18.76,-45.59,;17.43,-46.36,;17.43,-47.91,;16.1,-48.68,;16.09,-50.22,;16.08,-51.75,;17.63,-50.22,;14.55,-50.21,;18.76,-48.68,;20.1,-47.91,)|
Structure:
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