Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50199989
Substrate
n/a
Meas. Tech.
ChEMBL_422533 (CHEMBL911040)
Ki
4200000±n/a nM
Citation
 Lu, H; Silverman, RB Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors. J Med Chem 49:7404-12 (2006) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 2.6.1.19 | 2.6.1.22 | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | GABT_PIG | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
n/a
Mol. Mass.:
56633.06
Organism:
Sus scrofa
Description:
n/a
Residue:
500
Sequence:
MASVLLTRRLACSFRHNHRLLVPGWRHISQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM50199989
Synonyms:
(1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluoromethylethylidene)cyclopentane | CHEMBL220453
Type:
Small organic molecule
Emp. Form.:
C9H9F6NO2
Mol. Mass.:
277.1637
SMILES:
[#7]-[#6@H]1-[#6]-[#6@H](-[#6]\[#6]-1=[#6](\C(F)(F)F)C(F)(F)F)-[#6](-[#8])=O |r|
Structure:
Search PDB for entries with ligand similarity: