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Target
Group 10 secretory phospholipase A2
Ligand
BDBM50200327
Substrate
n/a
Meas. Tech.
ChEMBL_408914 (CHEMBL909439)
IC50
10000±n/a nM
Citation
 Muller, P; Lena, G; Boilard, E; Bezzine, S; Lambeau, G; Guichard, G; Rognan, D In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors. J Med Chem 49:6768-78 (2006) [PubMed]  Article 
Target
Name:
Group 10 secretory phospholipase A2
Synonyms:
Group X secretory phospholipase A2 | PA2GX_HUMAN | PLA2G10
Type:
PROTEIN
Mol. Mass.:
18153.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442449
Residue:
165
Sequence:
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
  
Inhibitor
Name:
BDBM50200327
Synonyms:
(E)-4-(6-Benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid | CHEMBL216316
Type:
Small organic molecule
Emp. Form.:
C16H19N3O4
Mol. Mass.:
317.3398
SMILES:
CN1CN(C\C=C\C(O)=O)C(=O)N[C@@H](Cc2ccccc2)C1=O
Structure:
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