Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM50200960
Substrate
n/a
Meas. Tech.
ChEMBL_422737 (CHEMBL909833)
Ki
20310±n/a nM
Citation
 Doshi, JM; Tian, D; Xing, C Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J Med Chem 49:7731-9 (2006) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM50200960
Synonyms:
CHEMBL216089 | ethyl 2-amino-6-(4-tert-butylphenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C27H30N2O5
Mol. Mass.:
462.5375
SMILES:
CCOC(=O)C(C#N)C1C(C(=O)OCC)C(=N)Oc2ccc(cc12)-c1ccc(cc1)C(C)(C)C
Structure:
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