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Target
Thymidine kinase 2, mitochondrial
Ligand
BDBM50201000
Substrate
n/a
Meas. Tech.
ChEMBL_422916 (CHEMBL908767)
IC50
390±n/a nM
Citation
 Hernandez, AI; Familiar, O; Negri, A; Rodríguez-Barrios, F; Gago, F; Karlsson, A; Camarasa, MJ; Balzarini, J; Pérez-Pérez, MJ N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem 49:7766-73 (2006) [PubMed]  Article 
Target
Name:
Thymidine kinase 2, mitochondrial
Synonyms:
KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31013.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333885
Residue:
265
Sequence:
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
  
Inhibitor
Name:
BDBM50201000
Synonyms:
4-[1,1-(diphenyl)-1-[(6-thymin-1-yl)hexyloxy]methyl]-N-methylbenzamide | CHEMBL219299
Type:
Small organic molecule
Emp. Form.:
C32H35N3O4
Mol. Mass.:
525.638
SMILES:
CNC(=O)c1ccc(cc1)C(OCCCCCCn1cc(C)c(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Structure:
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