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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50201443
Substrate
n/a
Meas. Tech.
ChEMBL_446748 (CHEMBL895927)
IC50
9±n/a nM
Citation
 Lee, S; Kim, T; Lee, BH; Yoo, SE; Lee, K; Yi, KY 3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors. Bioorg Med Chem Lett 17:1291-5 (2007) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
90771.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_862405
Residue:
815
Sequence:
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
  
Inhibitor
Name:
BDBM50201443
Synonyms:
CHEMBL395897 | N-(diaminomethylene)-5-(2,5-dichlorophenyl)-3-(dimethylamino)furan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C14H14Cl2N4O2
Mol. Mass.:
341.193
SMILES:
CN(C)c1cc(oc1C(=O)NC(N)=N)-c1cc(Cl)ccc1Cl
Structure:
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