Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 8
Ligand
BDBM50203894
Substrate
n/a
Meas. Tech.
ChEMBL_425774 (CHEMBL855766)
IC50
23.6±n/a nM
Citation
 Jenkins, TJ; Guan, B; Dai, M; Li, G; Lightburn, TE; Huang, S; Freeze, BS; Burdi, DF; Jacutin-Porte, S; Bennett, R; Chen, W; Minor, C; Ghosh, S; Blackburn, C; Gigstad, KM; Jones, M; Kolbeck, R; Yin, W; Smith, S; Cardillo, D; Ocain, TD; Harriman, GC Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem 50:566-84 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50203894
Synonyms:
CHEMBL374414 | N-(4-{[(1-butyrylpiperidin-4-yl)amino]sulfonyl}-1-naphthyl)-1-benzothiophene-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C28H29N3O4S2
Mol. Mass.:
535.678
SMILES:
CCCC(=O)N1CCC(CC1)NS(=O)(=O)c1ccc(NC(=O)c2cc3ccccc3s2)c2ccccc12
Structure:
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