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Target
Neuropeptide Y receptor type 2
Ligand
BDBM50205095
Substrate
n/a
Meas. Tech.
ChEMBL_447170 (CHEMBL897468)
EC50
33±n/a nM
Citation
 DeCarr, LB; Buckholz, TM; Milardo, LF; Mays, MR; Ortiz, A; Lumb, KJ A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice. Bioorg Med Chem Lett 17:1916-9 (2007) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42734.65
Organism:
Homo sapiens (Human)
Description:
NPY-Y2 NPY2R HUMAN::P49146
Residue:
381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
  
Inhibitor
Name:
BDBM50205095
Synonyms:
(S)-2-((S)-2-((2S,3R)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((R)-2-acetamido-3-mercaptopropanamido)-4-methylpentanamido)-5-guanidinopentanamido)-3-(1H-imidazol-5-yl)propanamido)-3-(4-hydroxyphenyl)propanamido)-4-methylpentanamido)-4-am | CHEMBL234198
Type:
Small organic molecule
Emp. Form.:
C84H136N28O20S
Mol. Mass.:
1890.219
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CS)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:84.87,51.52,101.102,29.28,67.68,121.122,4.4,83.84,wD:8.10,39.39,18.17,90.91,59.60,110.111,75.76,(-8.63,-37.13,;-8.63,-38.67,;-7.29,-39.44,;-9.96,-39.44,;-9.96,-40.98,;-11.29,-41.76,;-12.63,-40.99,;-12.63,-39.45,;-13.96,-41.76,;-13.96,-43.3,;-15.3,-44.07,;-15.29,-40.99,;-16.63,-41.76,;-17.96,-40.99,;-16.63,-43.3,;-8.63,-41.75,;-8.63,-43.29,;-7.3,-40.98,;-5.97,-41.77,;-5.97,-43.31,;-4.63,-44.08,;-4.63,-45.62,;-3.28,-46.37,;-3.3,-47.91,;-4.64,-48.68,;-1.96,-48.68,;-4.63,-41,;-4.63,-39.46,;-3.28,-41.75,;-1.95,-40.98,;-1.95,-39.44,;-.61,-38.67,;.8,-39.31,;1.83,-38.16,;1.06,-36.83,;-.45,-37.14,;-.61,-41.75,;-.61,-43.29,;.72,-40.97,;2.06,-41.74,;2.06,-43.28,;3.38,-44.05,;4.71,-43.28,;6.04,-44.05,;6.04,-45.59,;7.37,-46.35,;4.71,-46.36,;3.38,-45.59,;3.38,-40.97,;3.38,-39.43,;4.72,-41.74,;6.05,-40.96,;6.05,-39.42,;7.39,-38.65,;7.39,-37.11,;8.74,-39.42,;7.39,-41.73,;7.39,-43.27,;8.73,-40.97,;10.05,-41.76,;10.05,-43.3,;11.39,-44.07,;12.73,-43.28,;11.39,-45.61,;11.39,-40.99,;11.39,-39.45,;12.73,-41.75,;14.07,-40.98,;14.07,-39.44,;15.41,-38.67,;15.41,-37.13,;16.74,-39.44,;15.41,-41.75,;15.41,-43.29,;16.75,-40.98,;18.08,-41.75,;18.07,-43.29,;19.41,-44.07,;19.41,-45.61,;20.75,-43.31,;19.42,-40.98,;19.42,-39.44,;20.75,-41.76,;22.09,-40.98,;22.09,-39.44,;20.76,-38.67,;23.39,-38.65,;23.43,-41.75,;23.43,-43.29,;24.75,-40.96,;26.08,-41.73,;26.08,-43.27,;27.42,-44.04,;27.42,-45.58,;28.75,-46.35,;28.8,-47.89,;27.42,-48.64,;30.1,-48.65,;27.42,-40.96,;27.42,-39.42,;28.75,-41.73,;30.1,-40.99,;30.1,-39.45,;31.44,-38.68,;31.44,-37.14,;30.09,-36.36,;32.77,-36.37,;31.44,-41.76,;31.44,-43.3,;32.77,-40.98,;34.1,-41.76,;34.1,-43.3,;35.44,-44.07,;35.44,-45.61,;36.77,-46.37,;36.79,-47.91,;35.44,-48.67,;38.11,-48.67,;35.44,-40.99,;35.44,-39.45,;36.77,-41.76,;38.11,-40.99,;38.11,-39.45,;39.44,-38.68,;40.78,-39.45,;42.11,-38.68,;42.11,-37.14,;43.45,-36.37,;40.78,-36.37,;39.44,-37.14,;39.44,-41.76,;40.78,-40.99,;39.44,-43.3,)|
Structure:
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