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Target
Thymidine kinase
Ligand
BDBM50205241
Substrate
n/a
Meas. Tech.
ChEMBL_428150 (CHEMBL915787)
IC50
>500000±n/a nM
Citation
 Chitneni, SK; Deroose, CM; Balzarini, J; Gijsbers, R; Celen, SJ; de Groot, TJ; Debyser, Z; Mortelmans, L; Verbruggen, AM; Bormans, GM Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem 50:1041-9 (2007) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
KITH_HHV1 | TK | UL23
Type:
PROTEIN
Mol. Mass.:
40902.47
Organism:
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)
Description:
ChEMBL_474154
Residue:
376
Sequence:
MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM50205241
Synonyms:
3-(2'-deoxy-beta-D-ribofuranosyl)-6-(4-fluorophenyl)-2,3-dihydrofuro[2,3-d]p yrimidin-2-one | CHEMBL220065
Type:
Small organic molecule
Emp. Form.:
C17H15FN2O5
Mol. Mass.:
346.3098
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cc2cc(oc2nc1=O)-c1ccc(F)cc1
Structure:
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