Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50205281
Substrate
n/a
Meas. Tech.
ChEMBL_425907 (CHEMBL907967)
Ki
0.61±n/a nM
Citation
 Chang, LC; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; Westerhout, J; Spangenberg, T; Brussee, J; Ijzerman, AP 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem 50:828-34 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50205281
Synonyms:
2,6-diphenyl-8-isopropyl-1-deazapurine | CHEMBL221343 | LUF-5980
Type:
Small organic molecule
Emp. Form.:
C21H19N3
Mol. Mass.:
313.3957
SMILES:
CC(C)c1nc2c(cc(nc2[nH]1)-c1ccccc1)-c1ccccc1
Structure:
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