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TargetCyclin-dependent kinase 4
LigandBDBM50205468
Substrate/Competitorn/a
Meas. Tech.ChEMBL_442369
Ki>2000±n/a nM
Citation Chen, SChen, LLe, NTZhao, CSidduri, ALou, JPMichoud, CPortland, LJackson, NLiu, JJKonzelmann, FChi, FTovar, CXiang, QChen, YWen, YVassilev, LT Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors. Bioorg Med Chem Lett17:2134-8 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 4
Name:CDK4/CDK9
Synonyms:CDK4 | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:Enzyme Subunit
Mol. Mass.:33731.96
Organism:Homo sapiens (Human)
Description:P11802
Residue:303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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  Blast E-value cutoff:
BDBM50205468
NameBDBM50205468
Synonyms:(Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one | CHEMBL396377
TypeSmall organic molecule
Emp. Form.C13H9N3OS
Mol. Mass.255.295
SMILESNC1=NC(=O)C(S1)=Cc1ccc2ncccc2c1 |w:7.8,t:1|
Structure
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n/a