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Target
Cyclin-dependent kinase 1
Ligand
BDBM50206277
Substrate
n/a
Meas. Tech.
ChEMBL_442540 (CHEMBL892705)
IC50
1060±n/a nM
Citation
 Huang, S; Li, R; Connolly, PJ; Emanuel, S; Fuentes-Pesquera, A; Adams, M; Gruninger, RH; Seraj, J; Middleton, SA; Davis, JM; Moffat, DF Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1). Bioorg Med Chem Lett 17:2179-83 (2007) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50206277
Synonyms:
4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-(methylamino)ethyl)phenyl)pyrimidin-2-amine | CHEMBL393460
Type:
Small organic molecule
Emp. Form.:
C22H26ClN5
Mol. Mass.:
395.928
SMILES:
CNCCc1ccc(Nc2ncc(Cl)c(n2)-c2ccc(cc2)C(C)(C)N)cc1
Structure:
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