Target
M1 family aminopeptidase
Ligand
BDBM50062478
Substrate
n/a
Meas. Tech.
ChEMBL_428661 (CHEMBL915808)
IC50
790±n/a nM
Citation
 Flipo, MBeghyn, TLeroux, VFlorent, IDeprez, BPDeprez-Poulain, RF Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem 50:1322-34 (2007) [PubMed]  Article 
Target
Name:
M1 family aminopeptidase
Synonyms:
AMPN_PLAF7 | M1AAP | Zinc aminopeptidase | m1-family aminopeptidase
Type:
PROTEIN
Mol. Mass.:
126072.31
Organism:
Plasmodium falciparum (isolate FcB1 / Columbia)
Description:
ChEMBL_735637
Residue:
1085
Sequence:
MKLTKGCAYKYIIFTVLILANILYDNKKRCMIKKNLRISSCGIISRLLKSNSNYNSFNKNYNFTSAISELQFSNFWNLDILQKDIFSNIHNNKNKPQSYIIHKRLMSEKGDNNNNNHQNNNGNDNKKRLGSVVNNEENTCSDKRMKPFEEGHGITQVDKMNNNSDHLQQNGVMNLNSNNVENNNNNNSVVVKKNEPKIHYRKDYKPSGFIINNVTLNINIHDNETIVRSVLDMDISKHNVGEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKVNEFEIPGGRHGARFNDPHLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVVGHEYFHNYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIEDNLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESFNLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPNISNNLKEYLLRLTNKL
  
Inhibitor
Name:
BDBM50062478
Synonyms:
CHEMBL116641 | N-Hydroxy-2-isobutyl-N'-(3-phenyl-propyl)-malonamide | N1-hydroxy-2-isobutyl-N3-(3-phenylpropyl)malonamide
Type:
Small organic molecule
Emp. Form.:
C16H24N2O3
Mol. Mass.:
292.3734
SMILES:
CC(C)CC(C(=O)NO)C(=O)NCCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: