Reaction Details Report a problem with these data
Target
Phospholipase A2, major isoenzyme
Ligand
BDBM50206918
Substrate
n/a
Meas. Tech.
ChEMBL_428850 (CHEMBL917126)
IC50
39900±n/a nM
Citation
Touaibia, M; Djimdé, A; Cao, F; Boilard, E; Bezzine, S; Lambeau, G; Redeuilh, C; Lamouri, A; Massicot, F; Chau, F; Dong, CZ; Heymans, F Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem 50:1618-26 (2007) [PubMed] Article
More Info.:
Target
Name:
Phospholipase A2, major isoenzyme
Synonyms:
Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2
Type:
Hydrolase; monomer or homodimer
Mol. Mass.:
16279.83
Organism:
Sus scrofa (pig)
Description:
Purchased from Sigma.
Residue:
146
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
Inhibitor
Name:
BDBM50206918
Synonyms:
1,3-O-di[4-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)methylphenyl]-2-O-tetradecylglycerol | CHEMBL373918
Type:
Small organic molecule
Emp. Form.:
C35H48N4O7
Mol. Mass.:
636.7782
SMILES:
CCCCCCCCCCCCCCOC(COc1ccc(Cc2nc(=O)o[nH]2)cc1)COc1ccc(Cc2nc(=O)o[nH]2)cc1