Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50207020
Substrate
n/a
Meas. Tech.
ChEMBL_454791 (CHEMBL886819)
IC50
>2500000±n/a nM
Citation
 Wan, ZKFollows, BKirincich, SWilson, DBinnun, EXu, WJoseph-McCarthy, DWu, JSmith, MZhang, YLTam, MErbe, DTam, SSaiah, ELee, J Probing acid replacements of thiophene PTP1B inhibitors. Bioorg Med Chem Lett 17:2913-20 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50207020
Synonyms:
3-(allyloxy)-4,5-dibromothiophene-2-carboxylic acid | CHEMBL391996
Type:
Small organic molecule
Emp. Form.:
C8H6Br2O3S
Mol. Mass.:
342.004
SMILES:
OC(=O)c1sc(Br)c(Br)c1OCC=C
Structure:
Search PDB for entries with ligand similarity: