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Target
Glycine receptor subunit alpha-2
Ligand
BDBM50208075
Substrate
n/a
Meas. Tech.
ChEMBL_429275 (CHEMBL915382)
IC50
>100000±n/a nM
Citation
 Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem 50:1610-7 (2007) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-2
Synonyms:
GLRA2 | GLRA2_HUMAN
Type:
PROTEIN
Mol. Mass.:
52016.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_429275
Residue:
452
Sequence:
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
  
Inhibitor
Name:
BDBM50208075
Synonyms:
(1S,6R,8S,11S,13S,16R,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-18-one | CHEMBL224937
Type:
Small organic molecule
Emp. Form.:
C20H28O7
Mol. Mass.:
380.4321
SMILES:
C[C@@H]1CO[C@H]2C[C@@]34C5C[C@@H](C(C)(C)C)C33[C@@H](O)COC3O[C@]4(C(=O)O5)[C@@]12O
Structure:
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