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Target
Glycine receptor subunit alpha-1
Ligand
BDBM50208062
Substrate
n/a
Meas. Tech.
ChEMBL_429273 (CHEMBL915380)
IC50
>100000±n/a nM
Citation
 Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem 50:1610-7 (2007) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52635.39
Organism:
Homo sapiens (Human)
Description:
P23415
Residue:
457
Sequence:
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
  
Inhibitor
Name:
BDBM50208062
Synonyms:
(1R,6R,8S,11S)-8-tert-butyl-6,13-dimethoxy-2,4,14,17-tetraoxapentacyclo[8.5.2.0^{1,11}.0^{3,7}.0^{7,11}]heptadecane-5,15,16-trione | CHEMBL222405
Type:
Small organic molecule
Emp. Form.:
C19H24O9
Mol. Mass.:
396.3885
SMILES:
CO[C@H]1C(=O)OC2O[C@@]34C(=O)OC5C[C@@H](C(C)(C)C)C12[C@]35CC(OC)OC4=O
Structure:
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