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Target
Chymase
Ligand
BDBM50208224
Substrate
n/a
Meas. Tech.
ChEMBL_429291 (CHEMBL915852)
Ki
2.3±n/a nM
Citation
 Greco, MN; Hawkins, MJ; Powell, ET; Almond, HR; de Garavilla, L; Hall, J; Minor, LK; Wang, Y; Corcoran, TW; Di Cera, E; Cantwell, AM; Savvides, SN; Damiano, BP; Maryanoff, BE Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem 50:1727-30 (2007) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50208224
Synonyms:
2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carbamoyl)naphthalen-2-yl)-1-(naphthalen-1-yl)-2-oxoethylphosphonic acid | CHEMBL374027
Type:
Small organic molecule
Emp. Form.:
C40H35N2O6P
Mol. Mass.:
670.6895
SMILES:
CN(C1CCN(CC1)C(=O)c1ccc2ccccc2c1)C(=O)c1cc2ccccc2cc1C(=O)C(c1cccc2ccccc12)P(O)(O)=O
Structure:
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