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Target
Tyrosine-protein kinase HCK
Ligand
BDBM50209144
Substrate
n/a
Meas. Tech.
ChEMBL_455236 (CHEMBL906397)
IC50
>50000±n/a nM
Citation
Akritopoulou-Zanze, I; Albert, DH; Bousquet, PF; Cunha, GA; Harris, CM; Moskey, M; Dinges, J; Stewart, KD; Sowin, TJ Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett 17:3136-40 (2007) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase HCK
Synonyms:
HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59600.18
Organism:
Homo sapiens (Human)
Description:
P08631
Residue:
526
Sequence:
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Inhibitor
Name:
BDBM50209144
Synonyms:
2-(2-methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen-3-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-acetamide | CHEMBL245968
Type:
Small organic molecule
Emp. Form.:
C28H25N3O4S
Mol. Mass.:
499.581
SMILES:
COCCOCC(=O)Nc1cccc-2c1Cc1c-2n[nH]c1-c1csc(c1)C#CCOc1ccccc1