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Target
Baculoviral IAP repeat-containing protein 5
Ligand
BDBM50209198
Substrate
n/a
Meas. Tech.
ChEMBL_443470 (CHEMBL893728)
Kd
200±n/a nM
Citation
 Wendt, MD; Sun, C; Kunzer, A; Sauer, D; Sarris, K; Hoff, E; Yu, L; Nettesheim, DG; Chen, J; Jin, S; Comess, KM; Fan, Y; Anderson, SN; Isaac, B; Olejniczak, ET; Hajduk, PJ; Rosenberg, SH; Elmore, SW Discovery of a novel small molecule binding site of human survivin. Bioorg Med Chem Lett 17:3122-9 (2007) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 5
Synonyms:
API4 | Apoptosis inhibitor 4 | Apoptosis inhibitor survivin | BIRC5 | BIRC5_HUMAN | IAP4
Type:
PROTEIN
Mol. Mass.:
16386.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_443470
Residue:
142
Sequence:
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
  
Inhibitor
Name:
BDBM50209198
Synonyms:
CHEMBL234041 | N-(5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)-4-methoxy-N-methylcyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C29H26Cl2F3N3O4
Mol. Mass.:
608.436
SMILES:
COC1CCC(CC1)C(=O)N(C)Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1 |(1.17,-33.82,;-.16,-33.05,;-1.49,-33.82,;-1.5,-35.36,;-2.83,-36.13,;-4.16,-35.36,;-4.17,-33.82,;-2.83,-33.05,;-5.49,-36.14,;-6.82,-35.37,;-5.48,-37.68,;-4.15,-38.44,;-6.81,-38.45,;-6.81,-39.99,;-8.14,-40.76,;-8.14,-42.31,;-9.47,-43.08,;-6.81,-43.08,;-5.47,-42.31,;-5.47,-40.76,;-4.14,-39.98,;-4.13,-43.07,;-4.14,-44.62,;-2.81,-45.38,;-2.81,-46.92,;-1.47,-47.68,;-1.46,-49.21,;-2.8,-49.99,;-4.14,-49.22,;-4.14,-47.69,;-5.47,-46.91,;-.13,-49.98,;1.2,-50.74,;.64,-48.64,;-.88,-51.32,;-1.47,-44.61,;-.14,-45.38,;1.19,-46.15,;-1.48,-43.06,;-.15,-42.29,;-2.81,-42.3,)|
Structure:
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