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Target
Chymase
Ligand
BDBM50210121
Substrate
n/a
Meas. Tech.
ChEMBL_455355 (CHEMBL886130)
IC50
150±n/a nM
Citation
 Tanaka, T; Muto, T; Maruoka, H; Imajo, S; Fukami, H; Tomimori, Y; Fukuda, Y; Nakatsuka, T Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett 17:3431-4 (2007) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50210121
Synonyms:
6-(2-fluorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-diazepane-2,5-dione | CHEMBL395684
Type:
Small organic molecule
Emp. Form.:
C18H16ClFN2O4S
Mol. Mass.:
410.847
SMILES:
Fc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Structure:
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