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Target
Cyclin-dependent kinase 2
Ligand
BDBM50211446
Substrate
n/a
Meas. Tech.
ChEMBL_455593 (CHEMBL886373)
IC50
2672±n/a nM
Citation
 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett 17:3463-7 (2007) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50211446
Synonyms:
1-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-2-(methylamino)ethanone | CHEMBL393861
Type:
Small organic molecule
Emp. Form.:
C20H23ClN6O
Mol. Mass.:
398.889
SMILES:
CNCC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
Structure:
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