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Target
Estrogen receptor
Ligand
BDBM50212160
Substrate
n/a
Meas. Tech.
ChEMBL_438780 (CHEMBL889118)
Ki
0.24±n/a nM
Citation
 Richardson, TI; Frank, SA; Wang, M; Clarke, CA; Jones, SA; Ying, BP; Kohlman, DT; Wallace, OB; Shepherd, TA; Dally, RD; Palkowitz, AD; Geiser, AG; Bryant, HU; Henck, JW; Cohen, IR; Rudmann, DG; McCann, DJ; Coutant, DE; Oldham, SW; Hummel, CW; Fong, KC; Hinklin, R; Lewis, G; Tian, H; Dodge, JA Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety. Bioorg Med Chem Lett 17:3544-9 (2007) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50212160
Synonyms:
3-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)benzonitrile | CHEMBL243999
Type:
Small organic molecule
Emp. Form.:
C30H28N2O3
Mol. Mass.:
464.5549
SMILES:
Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(ccc2c1)-c1cccc(c1)C#N
Structure:
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