Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM18069
Substrate
n/a
Meas. Tech.
ChEMBL_439553 (CHEMBL888669)
IC50
190±n/a nM
Citation
Reynolds, RC; Campbell, SR; Fairchild, RG; Kisliuk, RL; Micca, PL; Queener, SF; Riordan, JM; Sedwick, WD; Waud, WR; Leung, AK; Dixon, RW; Suling, WJ; Borhani, DW Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. J Med Chem 50:3283-9 (2007) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
19884.75
Organism:
Mycobacterium avium
Description:
Recombinant Mycobacterium avium DHFR expressed in E. coli.
Residue:
181
Sequence:
MTRAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRPS