Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50215797
Substrate
n/a
Meas. Tech.
ChEMBL_456550 (CHEMBL922916)
IC50
110±n/a nM
Citation
 Wickens, PKluender, HDixon, JBrennan, CAchebe, FBacchiocchi, ABankston, DBierer, DBrands, MBraun, DBrown, MSChuang, CYDumas, JEnyedy, IHofilena, GHong, ZHousley, TJones, BKhire, UKreiman, CKumarasinghe, ELowinger, TOtt-Morgan, RPerkins, LPhillips, BSchoenleber, RScott, WJSheeler, RRedman, ASun, XTaylor, IWang, LWilhelm, SZhang, XZhang, MSullivan, ECarter, CMiglarese, MLevy, J SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer. Bioorg Med Chem Lett 17:4378-81 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50215797
Synonyms:
2-((2-cyanopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | CHEMBL248257
Type:
Small organic molecule
Emp. Form.:
C21H14F2N4O3
Mol. Mass.:
408.3577
SMILES:
FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(c3)C#N)cc2O1
Structure:
Search PDB for entries with ligand similarity: