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Target
Proteinase-activated receptor 1
Ligand
BDBM50215924
Substrate
n/a
Meas. Tech.
ChEMBL_447757 (CHEMBL896765)
IC50
285±n/a nM
Citation
 Xia, Y; Chackalamannil, S; Clasby, M; Doller, D; Eagen, K; Greenlee, WJ; Tsai, H; Agans-Fantuzzi, J; Ahn, HS; Boykow, GC; Hsieh, Y; Lunn, CA; Chintala, M Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring. Bioorg Med Chem Lett 17:4509-13 (2007) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50215924
Synonyms:
(3R,3aS,4S,4aS,9aR,E)-4-(2-(6-ethyl-5-phenylpyridin-2-yl)vinyl)-3-methyl-3,3a,4,4a,5,6,7,8-octahydronaphtho[2,3-c]furan-1(9aH)-one | CHEMBL232726
Type:
Small organic molecule
Emp. Form.:
C28H31NO2
Mol. Mass.:
413.5512
SMILES:
CCc1nc(\C=C\[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C=C3CCCC[C@@H]23)ccc1-c1ccccc1 |t:16|
Structure:
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