Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50216159
Substrate
n/a
Meas. Tech.
ChEMBL_448369 (CHEMBL898630)
IC50
16±n/a nM
Citation
 Hugon, BAnizon, FBailly, CGolsteyn, RMPierré, ALéonce, SHickman, JPfeiffer, BPrudhomme, M Synthesis and biological activities of isogranulatimide analogues. Bioorg Med Chem 15:5965-80 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50216159
Synonyms:
5-hydroxy-pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,8H)-dione | CHEMBL239698
Type:
Small organic molecule
Emp. Form.:
C16H9N3O3
Mol. Mass.:
291.261
SMILES:
Oc1ccc2[nH]c3c4cccn4c4C(=O)NC(=O)c4c3c2c1
Structure:
Search PDB for entries with ligand similarity: