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Target
Membrane-bound transcription factor site-1 protease
Ligand
BDBM50216183
Substrate
n/a
Meas. Tech.
ChEMBL_447771 (CHEMBL896780)
IC50
590±n/a nM
Citation
 Hay, BA; Abrams, B; Zumbrunn, AY; Valentine, JJ; Warren, LC; Petras, SF; Shelly, LD; Xia, A; Varghese, AH; Hawkins, JL; Van Camp, JA; Robbins, MD; Landschulz, K; Harwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett 17:4411-4 (2007) [PubMed]  Article 
Target
Name:
Membrane-bound transcription factor site-1 protease
Synonyms:
KIAA0091 | MBTP1_HUMAN | MBTPS1 | S1P | SKI1
Type:
PROTEIN
Mol. Mass.:
117773.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_641529
Residue:
1052
Sequence:
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
  
Inhibitor
Name:
BDBM50216183
Synonyms:
CHEMBL233573 | N-(2-chlorophenethyl)-4-(benzyloxy)-N-(pyrrolidin-3-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C26H27ClN2O2
Mol. Mass.:
434.958
SMILES:
Clc1ccccc1CCN(C1CCNC1)C(=O)c1ccc(OCc2ccccc2)cc1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: