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Target
Metabotropic glutamate receptor 7
Ligand
BDBM50217030
Substrate
n/a
Meas. Tech.
ChEMBL_440406 (CHEMBL890720)
EC50
625000±n/a nM
Citation
 Sibille, P; Lopez, S; Brabet, I; Valenti, O; Oueslati, N; Gaven, F; Goudet, C; Bertrand, HO; Neyton, J; Marino, MJ; Amalric, M; Pin, JP; Acher, FC Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. J Med Chem 50:3585-95 (2007) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 7
Synonyms:
GPRC1G | GRM7 | GRM7 protein | GRM7_HUMAN | MGLUR7 | Metabotropic glutamate receptor 7 | metabotropic glutamate 7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
102262.98
Organism:
Homo sapiens (Human)
Description:
Q14831
Residue:
915
Sequence:
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
  
Inhibitor
Name:
BDBM50217030
Synonyms:
(1S,2S)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid | CHEMBL227288
Type:
Small organic molecule
Emp. Form.:
C5H10NO5P
Mol. Mass.:
195.1104
SMILES:
N[C@]1(C[C@@H]1CP(O)(O)=O)C(O)=O
Structure:
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