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Target
Histone deacetylase 3
Ligand
BDBM50241188
Substrate
n/a
Meas. Tech.
ChEMBL_440469 (CHEMBL890785)
IC50
3162.28±n/a nM
Citation
 Dehmel, F; Ciossek, T; Maier, T; Weinbrenner, S; Schmidt, B; Zoche, M; Beckers, T Trithiocarbonates: exploration of a new head group for HDAC inhibitors. Bioorg Med Chem Lett 17:4746-52 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50241188
Synonyms:
CHEMBL242039 | Ethyl 2-(4-Methoxyphenyl)-2-oxoethyl Trithiocarbonate | trithiocarbonic acid ethyl ester 2-(4-methoxy-phenyl)-2-oxo-ethyl ester
Type:
Small organic molecule
Emp. Form.:
C12H14O2S3
Mol. Mass.:
286.433
SMILES:
CCSC(=S)SCC(=O)c1ccc(OC)cc1
Structure:
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