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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50217928
Substrate
n/a
Meas. Tech.
ChEMBL_448716 (CHEMBL897862)
Ki
1.4±n/a nM
Citation
 Elokdah, H; Li, D; McFarlane, G; Bernotas, RC; Robichaud, AJ; Magolda, RL; Zhang, GM; Smith, D; Schechter, LE Novel 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 agonists and antagonists. Bioorg Med Chem 15:6208-26 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50217928
Synonyms:
3-(6-chloro-imidazo[2,1-b]thiazole-5-sulfonyl)-1-(1-ethyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine | CHEMBL392541
Type:
Small organic molecule
Emp. Form.:
C18H20ClN5O2S2
Mol. Mass.:
437.967
SMILES:
CCN1CCC(C1)n1cc(c2cccnc12)S(=O)(=O)C1N2C=CSC2N=C1Cl |c:24,29|
Structure:
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