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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50218682
Substrate
n/a
Meas. Tech.
ChEMBL_444955 (CHEMBL894103)
IC50
16±n/a nM
Citation
Goldberg, DR; Hao, MH; Qian, KC; Swinamer, AD; Gao, DA; Xiong, Z; Sarko, C; Berry, A; Lord, J; Magolda, RL; Fadra, T; Kroe, RR; Kukulka, A; Madwed, JB; Martin, L; Pargellis, C; Skow, D; Song, JJ; Tan, Z; Torcellini, CA; Zimmitti, CS; Yee, NK; Moss, N Discovery and optimization of p38 inhibitors via computer-assisted drug design. J Med Chem 50:4016-26 (2007) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
Inhibitor
Name:
BDBM50218682
Synonyms:
CHEMBL243575 | N-[2-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-benzo[b]thiophen-7-yl]-6-cyclopropylamino-nicotinamide
Type:
Small organic molecule
Emp. Form.:
C30H33N5O5S2
Mol. Mass.:
607.744
SMILES:
COc1c(NC(=O)c2cc3cccc(NC(=O)c4ccc(NC5CC5)nc4)c3s2)cc(cc1NS(C)(=O)=O)C(C)(C)C