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Target
D(2) dopamine receptor
Ligand
BDBM50219939
Substrate
n/a
Meas. Tech.
ChEMBL_449064 (CHEMBL898269)
IC50
4±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50219939
Synonyms:
CHEMBL240693 | N-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)pyridine-3-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H30Cl2N4O2S
Mol. Mass.:
497.481
SMILES:
Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1Cl |wU:15.18,wD:12.11,(14.57,-10.28,;13.25,-9.5,;13.25,-7.96,;11.92,-7.19,;10.58,-7.96,;10.59,-9.49,;9.26,-10.25,;9.25,-11.79,;7.92,-12.55,;6.58,-11.78,;5.26,-12.55,;3.92,-11.78,;2.59,-12.55,;1.25,-11.78,;-.09,-12.55,;-.09,-14.1,;1.25,-14.87,;2.59,-14.1,;-1.42,-14.9,;-2.77,-14.14,;-3.53,-15.48,;-2,-12.8,;-4.1,-13.37,;-5.44,-14.14,;-6.77,-13.38,;-6.78,-11.83,;-5.43,-11.05,;-4.1,-11.83,;6.58,-10.25,;7.92,-9.48,;11.92,-10.27,;11.9,-11.81,)|
Structure:
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