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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50220072
Substrate
n/a
Meas. Tech.
ChEMBL_446023 (CHEMBL895119)
IC50
27±n/a nM
Citation
 Conchon, E; Anizon, F; Aboab, B; Prudhomme, M Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide. J Med Chem 50:4669-80 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50220072
Synonyms:
11-hydroxybenzo[a]pyrrolo[3,4-c]carbazole-1,3,4,7(2H,8H)-tetraone | CHEMBL243931
Type:
Small organic molecule
Emp. Form.:
C18H8N2O5
Mol. Mass.:
332.2665
SMILES:
Oc1ccc2nc3c(c2c1)c1c(c2c3c(O)ccc2=O)c(=O)[nH]c1=O
Structure:
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