Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50220347
Substrate
n/a
Meas. Tech.
ChEMBL_446076 (CHEMBL895171)
IC50
19000±n/a nM
Citation
 Cisneros, JA; Vandevoorde, S; Ortega-Gutiérrez, S; Paris, C; Fowler, CJ; López-Rodríguez, ML Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem 50:5012-23 (2007) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
  
Inhibitor
Name:
BDBM50220347
Synonyms:
(+/-)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate | CHEMBL244156
Type:
Small organic molecule
Emp. Form.:
C23H36O3
Mol. Mass.:
360.5301
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC1CO1 |w:23.22|
Structure:
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