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Target
Monoglyceride lipase
Ligand
BDBM50220351
Substrate
n/a
Meas. Tech.
ChEMBL_446075 (CHEMBL895170)
IC50
3500±n/a nM
Citation
 Cisneros, JA; Vandevoorde, S; Ortega-Gutiérrez, S; Paris, C; Fowler, CJ; López-Rodríguez, ML Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem 50:5012-23 (2007) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
  
Inhibitor
Name:
BDBM50220351
Synonyms:
(S,5Z,8Z,11Z,14Z)-N-((tetrahydrofuran-2-yl)methyl)icosa-5,8,11,14-tetraenamide | CHEMBL244354
Type:
Small organic molecule
Emp. Form.:
C25H41NO2
Mol. Mass.:
387.5985
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC[C@@H]1CCCO1
Structure:
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