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TargetEquilibrative Nucleoside Transporter 1 (ENT1)
LigandBDBM50222758
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458014
Ki 394±n/a nM
Citation Gupte, ABuolamwini, JK Novel C2-purine position analogs of nitrobenzylmercaptopurine riboside as human equilibrative nucleoside transporter 1 inhibitors. Bioorg Med Chem15:7726-37 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Equilibrative Nucleoside Transporter 1 (ENT1)
Name:Equilibrative nucleoside transporter 1
Synonyms:ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Nucleoside transporter, es-type | Solute carrier family 29 member 1
Type:Multi-pass membrane protein
Mol. Mass.:50225.92
Organism:Homo sapiens (Human)
Description:n/a
Residue:456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50222758
NameBDBM50222758
Synonyms:2-phenethylamino-6-(4-nitrobenzylthio)-9-beta-D-ribofuranosylpurine | CHEMBL428031
TypeSmall organic molecule
Emp. Form.C25H26N6O6S
Mol. Mass.538.576
SMILESOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(SCc3ccc(cc3)[N+]([O-])=O)nc(NCCc3ccccc3)nc12
Structure
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n/a