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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50223451
Substrate
n/a
Meas. Tech.
ChEMBL_458175 (CHEMBL924433)
IC50
360±n/a nM
Citation
 Garbaccio, RM; Huang, S; Tasber, ES; Fraley, ME; Yan, Y; Munshi, S; Ikuta, M; Kuo, L; Kreatsoulas, C; Stirdivant, S; Drakas, B; Rickert, K; Walsh, ES; Hamilton, KA; Buser, CA; Hardwick, J; Mao, X; Beck, SC; Abrams, MT; Tao, W; Lobell, R; Sepp-Lorenzino, L; Hartman, GD Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. Bioorg Med Chem Lett 17:6280-5 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50223451
Synonyms:
CHEMBL248995 | methyl 9-chloro-1-oxo-1,2-dihydrobenzo[h]isoquinoline-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H10ClNO3
Mol. Mass.:
287.698
SMILES:
COC(=O)c1cc2cc[nH]c(=O)c2c2cc(Cl)ccc12
Structure:
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