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Target
Alpha-1D adrenergic receptor
Ligand
BDBM50213513
Substrate
n/a
Meas. Tech.
ChEMBL_450224 (CHEMBL900499)
Ki
34±n/a nM
Citation
 Chiu, G; Li, S; Cai, H; Connolly, PJ; Peng, S; Stauber, K; Pulito, V; Liu, J; Middleton, SA Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Bioorg Med Chem Lett 17:6123-8 (2007) [PubMed]  Article 
Target
Name:
Alpha-1D adrenergic receptor
Synonyms:
ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60485.82
Organism:
Homo sapiens (Human)
Description:
adrenergic Alpha1D ADRA1D HUMAN::P25100
Residue:
572
Sequence:
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
  
Inhibitor
Name:
BDBM50213513
Synonyms:
CHEMBL228278 | N-((1r,4r)-4-(4-(2-cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H38N2O5S
Mol. Mass.:
514.677
SMILES:
COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1 |wU:17.21,wD:14.14,(32.87,-18.24,;31.33,-18.26,;30.57,-19.6,;29.02,-19.61,;28.27,-20.96,;29.05,-22.28,;30.59,-22.27,;31.35,-20.93,;32.89,-20.92,;33.67,-22.24,;28.29,-23.62,;26.94,-22.88,;29.64,-24.36,;27.57,-24.98,;26.03,-25.04,;25.21,-23.74,;23.67,-23.79,;22.96,-25.16,;23.78,-26.46,;25.31,-26.4,;21.42,-25.21,;20.7,-26.58,;19.17,-26.64,;18.34,-25.34,;19.05,-23.98,;20.59,-23.91,;16.81,-25.41,;16.09,-26.78,;14.55,-26.84,;13.73,-25.54,;14.43,-24.18,;15.97,-24.1,;16.67,-22.73,;15.84,-21.44,;15.77,-19.91,;14.47,-20.74,)|
Structure:
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