Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50224046
Substrate
n/a
Meas. Tech.
ChEMBL_450409 (CHEMBL900693)
Ki
202±n/a nM
Citation
 Stern, E; Muccioli, GG; Bosier, B; Hamtiaux, L; Millet, R; Poupaert, JH; Hénichart, JP; Depreux, P; Goossens, JF; Lambert, DM Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality. J Med Chem 50:5471-84 (2007) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50224046
Synonyms:
((+/-)-N3-(1-(1-adamantyl)ethyl)-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide | (+)-N3-(1-(1-adamantyl)ethyl)-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide | (-)-N3-(1-(1-adamantyl)ethyl)-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide | CHEMBL236333
Type:
Small organic molecule
Emp. Form.:
C27H36N2O2
Mol. Mass.:
420.5869
SMILES:
CCCCCn1cc(C(=O)NC(C)C23CC4CC(CC(C4)C2)C3)c(=O)c2ccccc12 |w:11.11,TLB:11:13:16:20.18.19,THB:18:17:14:20.19.21,18:19:16.17.22:14,21:19:16:22.13.14,21:13:16:20.18.19|
Structure:
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