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Target
Transthyretin
Ligand
BDBM50225220
Substrate
n/a
Meas. Tech.
ChEMBL_451108 (CHEMBL900187)
pH
4.4±n/a
IC50
7170±n/a nM
Comments
extracted
Citation
 Gupta, S; Chhibber, M; Sinha, S; Surolia, A Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem 50:5589-99 (2007) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50225220
Synonyms:
CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine | dextrothyroxine
Type:
Small organic molecule
Emp. Form.:
C15H11I4NO4
Mol. Mass.:
776.87
SMILES:
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
Structure:
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