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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50225277
Substrate
n/a
Meas. Tech.
ChEMBL_459698 (CHEMBL942830)
IC50
3710±n/a nM
Citation
 Feng, Y; Carroll, AR; Addepalli, R; Fechner, GA; Avery, VM; Quinn, RJ Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors. J Nat Prod 70:1790-2 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50225277
Synonyms:
2,8-dihydroxy-6-(3,3',4'-trihydroxy-biphenyl-4-yloxy)-dibenzofuran-3-carboxylic acid | CHEMBL251261
Type:
Small organic molecule
Emp. Form.:
C25H16O9
Mol. Mass.:
460.3891
SMILES:
OC(=O)c1cc2oc3c(Oc4ccc(cc4O)-c4ccc(O)c(O)c4)cc(O)cc3c2cc1O
Structure:
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