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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM25272
Substrate
n/a
Meas. Tech.
ChEMBL_451566 (CHEMBL901776)
IC50
260±n/a nM
Citation
 Zhang, Y; Hudock, MP; Krysiak, K; Cao, R; Bergan, K; Yin, F; Leon, A; Oldfield, E Activity of sulfonium bisphosphonates on tumor cell lines. J Med Chem 50:6067-79 (2007) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM25272
Synonyms:
CHEMBL238046 | bisphosphonate, 25 | hydrogen {2-[dodecyl(methyl)sulfanylium]-1-phosphonoethyl}phosphonate
Type:
Small organic molecule
Emp. Form.:
C15H34O6P2S
Mol. Mass.:
404.439
SMILES:
CCCCCCCCCCCC[S+](C)CC(P(O)(O)=O)P(O)([O-])=O
Structure:
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