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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50233562
Substrate
n/a
Meas. Tech.
ChEMBL_462398 (CHEMBL927214)
IC50
8.2±n/a nM
Citation
 Yu, Y; Dwyer, MP; Chao, J; Aki, C; Chao, J; Purakkattle, B; Rindgen, D; Bond, R; Mayer-Ezel, R; Jakway, J; Qiu, H; Hipkin, RW; Fossetta, J; Gonsiorek, W; Bian, H; Fan, X; Terminelli, C; Fine, J; Lundell, D; Merritt, JR; He, Z; Lai, G; Wu, M; Taveras, A Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists. Bioorg Med Chem Lett 18:1318-22 (2008) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50233562
Synonyms:
3-(3,4-dioxo-2-(1-(4-(thiophen-3-yl)furan-2-yl)propylamino)cyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL253705
Type:
Small organic molecule
Emp. Form.:
C24H23N3O5S
Mol. Mass.:
465.522
SMILES:
CCC(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)-c1ccsc1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: