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Target
Protein kinase C epsilon type
Ligand
BDBM50269146
Substrate
n/a
Meas. Tech.
ChEMBL_528398 (CHEMBL974186)
IC50
18500±n/a nM
Citation
 Brauers, G; Edrada, RA; Ebel, R; Proksch, P; Wray, V; Berg, A; Gräfe, U; Schächtele, C; Totzke, F; Finkenzeller, G; Marme, D; Kraus, J; Münchbach, M; Michel, M; Bringmann, G; Schaumann, K Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: novel inhibitors of protein kinases. J Nat Prod 63:739-45 (2000) [PubMed]  Article 
Target
Name:
Protein kinase C epsilon type
Synonyms:
KPCE_MOUSE | Pkce | Pkcea | Prkce | Protein kinase C epsilon
Type:
PROTEIN
Mol. Mass.:
83566.28
Organism:
Mus musculus
Description:
ChEMBL_528398
Residue:
737
Sequence:
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLAAGAESPQPASGNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSYFGEDLMP
  
Inhibitor
Name:
BDBM50269146
Synonyms:
(R)-1,3,6,8-tetrahydroxy-2-(1-hydroxyethyl)anthracene-9,10-dione | CHEMBL524820
Type:
Small organic molecule
Emp. Form.:
C16H12O7
Mol. Mass.:
316.2623
SMILES:
C[C@@H](O)c1c(O)cc2C(=O)c3cc(O)cc(O)c3C(=O)c2c1O |r|
Structure:
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