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Target
DNA topoisomerase
Ligand
BDBM22984
Substrate
n/a
Meas. Tech.
ChEMBL_509260 (CHEMBL996004)
IC50
>200000±n/a nM
Citation
 Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod 64:204-7 (2001) [PubMed]  Article 
Target
Name:
DNA topoisomerase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
111544.55
Organism:
Bos taurus
Description:
ChEMBL_509260
Residue:
1002
Sequence:
MIFPAAHRALRGLPRPGTRALTRAAMEVALRGVRKILCVAEKNDAAKGIADLLSGGRMRRREGLSRFNKIYEFDYHLCGQNVTMVMTSVSGHLLAHDFRMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLEREAQQCQALVIWTDCDREGENIGFEVIHVCKAVKPSLQVLRARFSEITTRAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIRVTHDHRDGVVEFSWKRHRLFNHTACLVLYQMCMEDPRAMVVEVRSKAKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGPTPRNGNKSDQAHPPIHPTKYTDSLQGDEQRLYELIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAATEVAPQDALPAVPEPIRKCPQCSRDMVLKTRKSGGFYLGCTGFPECRSAVWFPDSVLEASRDVSVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFVGCIGGCDETLREILALRFSQGAARVSQPASQTSGYLQASQSLNRMDSGQQGQPRPPVTRPSKALTRTLPPPAVESESNSVTCNCGQEALLLTVRKEGPNQGRQFYKCGSGGCSFFLWADSGHPGAGPPSSASRPPGGPLEHPPGSGTLLGGSSRPGSGGSGGASCLCGQPAVTRTVQKEGPNQGRQFHTCAQPREHQCGFFQWVDENVAPGTFGGPLWPGSRRGTQGLEARSKRPRAGSSDTGSATKKPRKCSLCHQPGHTRPFCPQNR
  
Inhibitor
Name:
BDBM22984
Synonyms:
(8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione | Adriamycin | Adriblastina | CHEMBL53463 | Doxil | Doxorubicin
Type:
Antibiotic
Emp. Form.:
C27H29NO11
Mol. Mass.:
543.5193
SMILES:
COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |r|
Structure:
Search PDB for entries with ligand similarity: