Reaction Details Report a problem with these data
Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50260246
Substrate
n/a
Meas. Tech.
ChEMBL_509302 (CHEMBL996874)
Ki
1470±n/a nM
Citation
 Chen, D; Liao, J; Li, N; Zhou, C; Liu, Q; Wang, G; Zhang, R; Zhang, S; Lin, L; Chen, K; Xie, X; Nan, F; Young, AA; Wang, MW A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc Natl Acad Sci U S A 104:943-8 (2007) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rattus norvegicus
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50260246
Synonyms:
1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid | CHEMBL449327
Type:
Small organic molecule
Emp. Form.:
C54H52N4O16S2
Mol. Mass.:
1077.138
SMILES:
COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |(.32,-12.51,;1.08,-13.85,;2.62,-13.86,;3.39,-12.53,;4.93,-12.54,;5.69,-13.87,;4.93,-15.19,;3.38,-15.19,;2.61,-16.52,;1.07,-16.52,;.3,-15.18,;.3,-17.85,;-1.23,-18.01,;-1.55,-19.51,;-.22,-20.29,;.93,-19.26,;4.93,-10.99,;4.93,-9.45,;4.92,-7.9,;3.56,-7.14,;2.02,-7.16,;3.56,-5.61,;4.89,-4.84,;4.89,-3.3,;3.55,-2.53,;3.55,-.99,;4.88,-.21,;6.22,-.98,;4.87,1.33,;6.21,2.1,;7.53,2.89,;6.99,.77,;5.43,3.43,;2.22,-3.31,;2.23,-4.85,;6.47,-9.45,;6.46,-7.9,;5.7,-6.57,;6.46,-5.25,;8,-5.24,;8.77,-3.91,;10.31,-3.9,;11.08,-5.24,;11.07,-2.57,;12.6,-2.4,;12.92,-.9,;11.58,-.13,;10.44,-1.16,;8.77,-6.57,;10.31,-6.57,;11.08,-7.91,;8,-7.9,;6.47,-10.99,;6.48,-12.53,;7.83,-13.3,;9.37,-13.29,;7.82,-14.84,;6.48,-15.6,;6.47,-17.14,;7.8,-17.92,;7.8,-19.46,;6.46,-20.22,;5.13,-19.45,;6.45,-21.76,;5.12,-22.53,;3.77,-23.29,;5.88,-23.87,;4.36,-21.19,;9.14,-17.14,;9.15,-15.61,;8.02,-11.01,;8.77,-12.35,;8.8,-9.68,;3.39,-9.44,;2.62,-8.1,;2.61,-10.77,)|
Structure:
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