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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50216165
Substrate
n/a
Meas. Tech.
ChEMBL_530558 (CHEMBL968469)
IC50
80±n/a nM
Citation
 Conchon, E; Anizon, F; Aboab, B; Golsteyn, RM; Léonce, S; Pfeiffer, B; Prudhomme, M Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone. Eur J Med Chem 43:282-92 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50216165
Synonyms:
1,11-dihydro-1,3,5,11-tetraaza-benzo[a]trindene-4,6-dione | 3,11-Dihydro-1,3,5,11-tetraaza-benzo[a]trindene-4,6-dione | CHEMBL240747 | granulatimide
Type:
Small organic molecule
Emp. Form.:
C15H8N4O2
Mol. Mass.:
276.2496
SMILES:
O=C1NC(=O)c2c1c1[nH]cnc1c1[nH]c3ccccc3c21
Structure:
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