Reaction Details Report a problem with these data
Target
Ceramide glucosyltransferase
Ligand
BDBM18355
Substrate
n/a
Meas. Tech.
ChEMBL_534411 (CHEMBL970437)
IC50
22900±n/a nM
Citation
Walden, CM; Sandhoff, R; Chuang, CC; Yildiz, Y; Butters, TD; Dwek, RA; Platt, FM; van der Spoel, AC Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. J Biol Chem 282:32655-64 (2007) [PubMed] Article
More Info.:
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_MOUSE | Ugcg
Type:
PROTEIN
Mol. Mass.:
44844.15
Organism:
Mus musculus
Description:
ChEMBL_809643
Residue:
394
Sequence:
MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
Inhibitor
Name:
BDBM18355
Synonyms:
(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol | CHEMBL1029 | MIGLUSTAT | N-Butyl-DNJ | US20230339856, Compound NB-DNJ | US9181184, 5
Type:
Small organic molecule
Emp. Form.:
C10H21NO4
Mol. Mass.:
219.278
SMILES:
CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO